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brca-mast-cells-2026

Analysis code accompanying

Kirchmair et al., Genes & Immunity (2026)

This repository contains the code to reproduce the analysis of transcriptional signatures of mast cells in public breast cancer cohorts, as described below.

METABRIC

Data source: cBioPortal
Analysis script: analysis/METABRIC.Rmd

TCGA-BRCA

Data source: GDC
Analysis script: analysis/TCGA-BRCA.Rmd

Single-cell atlas (Chen et al.)

Data source: CELLxGENE
Analysis script: analysis/scRNAseq.Rmd

Paper figures can be reproduced from the results by running analysis/Figures.Rmd.
Analyses were performed in R 4.5.1.

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Analysis of mast cells in public breast cancer cohorts

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