Keep to one page (~250–400 words). Lead with the advance and its broad significance. Replace every [bracket]. Delete this note before sending.
[Date]
Dr. [Editor Name] Editor, Science American Association for the Advancement of Science
Dear Dr. [Editor Name],
We submit our manuscript, "[Declarative title]," for consideration as a [Report / Research Article] in Science.
[Opening claim — the advance + why it matters broadly.] We show that [surprising, general result], which means [consequence for a broad field]. [One sentence quantifying the headline effect.]
[Why Science — broad significance.] This result will interest not only [your subfield] but also [community 2] and [community 3], because [the cross-field implication]. It is timely because [why-now trigger: new method / new scale / ripe controversy / newly testable prediction / urgent real-world event].
[What's new vs. prior and concurrent work.] Unlike [closest prior work], which [limitation], our study [decisive distinction]. We are aware of [concurrent work, if any] and our advance differs in that [distinction].
The manuscript has not been published previously and is not under consideration elsewhere. All authors have approved the submission and declare [no competing interests / the interests listed in the disclosure].
[Optional: We suggest the following reviewers for their expertise in [area]: [names]. We respectfully request that [name] not review this work because [brief reason].]
[Optional: Related to this submission, we have [manuscript] in press/under review at [venue].]
Thank you for considering our work.
Sincerely, [Corresponding author name, on behalf of all authors] [Affiliation] · [email] · [ORCID]