Question about using Hi-C and H3K27ac ChIP-seq data for hichipper-based loop calling

[zhang-tong8]

HI,
Currently, I do not have HiChIP data, so I am trying to use Hi-C data together with H3K27ac ChIP-seq data to approximate a HiChIP-like analysis.  If I use this strategy to call loops, should the resulting loops be considered real chromatin loops? Alternatively, is it possible to set a threshold to identify more reliable loops from this analysis?

I would like to ask whether this approach is reasonable and feasible.

Thank you very much for your time and help.