| layout | rule |
|---|---|
| id | GORULE:0000038 |
| title | Annotations using ISS/ISA/ISO evidence should refer to a gene product (in the 'with' column) where there exists another annotation with the same or a more granular term using experimental evidence |
| type | report |
| fail_mode | soft |
| status | proposed |
| contact | go-quality@mailman.stanford.edu |
For annotations by ISO, ISA or ISS, the annotations of the gene product (col 8 info in the GAF) should be checked to ensure that an annotation exists to the same or a more granular term. For instance:
Gene Product 1 | GO:1233456 | ISS/ISO/ISA | with: Gene Product 2 Gene Product 2 | GO:1233456 (or a descentant) | EXP (or a descendant)
Allowed evidence codes for the primary annotations: EXP, IMP, IDA, IPI, IEP, IGI, HTP, HMP, HDA, HEP, HGI.